Longevity
The evidence, the grift, and the narrow strip of usefulness in between.
The longevity desk is a skeptical one. We cover rapamycin, senolytics, epigenetic clocks, the VO₂ max conversation, and the body-of-evidence standard we wish more of the industry held itself to. Where the science is strong we say so; where it is sold ahead of itself we say that too.
This Week's Feature
Rapamycin Is Still the Most Interesting Drug in Longevity
Year three of the first long-term healthy-adults trial just published. The results are smaller than the evangelists hoped and larger than the skeptics predicted. Both camps have some explaining to do.
Read the feature → Longevity Biological Age Tests Are Selling Certainty They Cannot Deliver
Horvath, GrimAge, PhenoAge — the three major epigenetic clocks are impressive science and underwhelming products. The reason comes down to what a clock can and cannot do for an individual.
Longevity The Hunger Set Point Theory, Revisited
The body-weight set point is either the most useful concept in obesity medicine or the most misused. A careful look at what forty years of evidence does and does not support.